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expand all sections collapse all sections  biological_process Term "apoptotic process" (GO:0006915)
Term Name apoptotic process
Term Accession GO:0006915
Aspect biological_process
Synonyms (10) apoptosis, apoptotic cell death, apoptotic program, apoptotic programmed cell death, cell suicide, cellular suicide, GO:0008632, programmed cell death by apoptosis, signaling (initiator) caspase activity, type I programmed cell death
Definition A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
Comment None
Source Ontology Database The GO browser of Gene Ontology Database
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